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Synthesis and Biological Evaluation of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxins as Potential Anticancer Agents

✍ Scribed by Pitta Bhaskar Reddy; Satyam Kumar Agrawal; Swaran Singh; Bilal A. Bhat; Ajit K. Saxena; Halmuthur M. Sampath Kumar; Gulam N. Qazi

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
206 KB
Volume
5
Category
Article
ISSN
1612-1872

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✦ Synopsis

Abstract

A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐7, and SF‐295). The compounds 9b, 9c, 9e, 9f, and 9h showed significant cytotoxic activities especially against HT‐29, HCT‐15, 502713 cell lines.

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