## Abstract A series of 4β‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin analogues have been synthesized with high regio‐selectivity by employing copper(I)‐catalyzed 1,3‐dipolar cycloaddition of 1‐__O__‐propargyl monosaccharides with C4β‐azido podophyllotoxin and C4β‐azido‐4′‐__O__‐demethyl p
Synthesis and Biological Evaluation of 4α/4β-Imidazolyl Podophyllotoxin Analogues as Antitumor Agents
✍ Scribed by Hai Shang; Hong Chen; Dongmei Zhao; Xiaowei Tang; Yongfeng Liu; Li Pan; Maosheng Cheng
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 135 KB
- Volume
- 345
- Category
- Article
- ISSN
- 0365-6233
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## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐