## Abstract A series of 4β‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin analogues have been synthesized with high regio‐selectivity by employing copper(I)‐catalyzed 1,3‐dipolar cycloaddition of 1‐__O__‐propargyl monosaccharides with C4β‐azido podophyllotoxin and C4β‐azido‐4′‐__O__‐demethyl p
ChemInform Abstract: Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents.
✍ Scribed by Pitta B. Reddy; David V. Paul; Satyam K. Agrawal; Ajit K. Saxena; Halmuthur M. S. Kumar; Ghulam N. Qazi
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 30 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
📜 SIMILAR VOLUMES
## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐
## Abstract The title compounds (III) are evaluated for their cytotoxicity against the human cancer cell lines SF‐295, A‐549, PC‐3, Hep‐2, HCT‐15 and MCF‐7.