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ChemInform Abstract: Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents.

✍ Scribed by Pitta B. Reddy; David V. Paul; Satyam K. Agrawal; Ajit K. Saxena; Halmuthur M. S. Kumar; Ghulam N. Qazi


Publisher
John Wiley and Sons
Year
2008
Weight
30 KB
Volume
39
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Design, Synthesis, and Biological Testin
✍ Pitta B. Reddy; David V. Paul; Satyam K. Agrawal; Ajit K. Saxena; Halmuthur M. S 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 495 KB 👁 1 views

## Abstract A series of 4β‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin analogues have been synthesized with high regio‐selectivity by employing copper(I)‐catalyzed 1,3‐dipolar cycloaddition of 1‐__O__‐propargyl monosaccharides with C4β‐azido podophyllotoxin and C4β‐azido‐4′‐__O__‐demethyl p

Synthesis and Biological Evaluation of 4
✍ Pitta Bhaskar Reddy; Satyam Kumar Agrawal; Swaran Singh; Bilal A. Bhat; Ajit K. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 1 views

## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐