ChemInform Abstract: Synthesis of Novel 4β-(1,2,3-Triazol-1-yl)podophyllotoxins as Potential Antitumor Drugs.
✍ Scribed by Lan Tao; Yan-Guang Wang; Cheng Ma; Bing Zheng; Yao-Zu Chen
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 32 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐
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## Abstract A series of 4β‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin analogues have been synthesized with high regio‐selectivity by employing copper(I)‐catalyzed 1,3‐dipolar cycloaddition of 1‐__O__‐propargyl monosaccharides with C4β‐azido podophyllotoxin and C4β‐azido‐4′‐__O__‐demethyl p
## Abstract The title compounds (III) are evaluated for their cytotoxicity against the human cancer cell lines SF‐295, A‐549, PC‐3, Hep‐2, HCT‐15 and MCF‐7.