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Synthesis of 4β-triazole-podophyllotoxin derivatives by azide–alkyne cycloaddition and biological evaluation as potential antitumor agents

✍ Scribed by Hong Chen; Song Zuo; Xiaochen Wang; Xiaowei Tang; Ming Zhao; Yanling Lu; Liting Chen; Jing Liu; Yongfeng Liu; Dailin Liu; Shi Zhang; Tan Li

Book ID
113583056
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
553 KB
Volume
46
Category
Article
ISSN
0223-5234

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Synthesis and Biological Evaluation of 4
Synthesis and Biological Evaluation of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxins as Potential Anticancer Agents
✍ Pitta Bhaskar Reddy; Satyam Kumar Agrawal; Swaran Singh; Bilal A. Bhat; Ajit K. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 1 views

## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐