𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and central nervous system stimulant activity of 5,8-methanoquinazolines fused with imidazole, thiadiazole, pyrimidine and 1,3,5-triazine

✍ Scribed by Sbin-Ichi Nagai; Taisei Ueda; Akito Nagatsu; Keiko Nakaoka; Nobutoshi Murakami; Jinsaku Sakakibara; Michiko Fujita; Yoshihiro Hotta

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
287 KB
Volume
35
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

5,8‐Methanoquinazolines fused with imidazoles 4a‐4b, thiadiazoles 5–6, pyrimidines 7, 9, 11 and 12, and 1,3,5‐triazine 13 were prepared starting from (5__R__,8__S__)‐2‐amino‐8,9,9‐trimethyl‐5,6,7,8‐tetrahydro‐5,8‐methanoquinazoline 3. Most compounds possessed central nervous system stimulant activities.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis and Centr
ChemInform Abstract: Synthesis and Central Nervous System Stimulant Activity of 5,8-Methanoquinazolines Fused with Imidazole, Thiadiazole, Pyrimidine, and 1,3,5-Triazine.
✍ S. NAGAI; T. UEDA; A. NAGATSU; K. NAKAOKA; N. MURAKAMI; J. SAKAKIBARA; M. FUJITA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 39 KB 👁 2 views

Synthesis and Central Nervous System Stimulant Activity of 5,8-Methanoquinazolines Fused with Imidazole, Thiadiazole, Pyrimidine, and1,3,5-Triazine. -The synthesis of a variety of new camphor-pyrimidines fused with azoles [cf. (VII), (XV), (XVI)], pyrimidines [cf. (IX), (XIII)], and triazine (XI) f

Synthesis and potential central nervous
Synthesis and potential central nervous system stimulant activity of 5,8-methanoquinazolines and bornano-triazines fused with imidazole and pyrimidine
✍ Shinichi Nagai; Takamasa Miyachi; Tetsu Nakane; Taisei Ueda; Yasuhiro Uozumi 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 32 KB

## Abstract Starting from 3‐chloro‐5,8‐methanoquinazoline **1** and 3‐chloro‐bornano[1,2,4]triazine **7**, the novel 5,8‐methanoquinazolines **5a‐b** and bornano[1,2,4]triazines **10a‐b** fused with imidazole and pyrimidine were prepared. None of these compounds showed any satisfactory central nerv

Synthesis and central nervous system sti
Synthesis and central nervous system stimulant activity of 5,8-methanoquinazolines fused with 1,2,4-triazole, tetrazoleand 1,2,4-triazine
✍ Shin-Icbi Nagai; Taisei Ueda; Satoe Sugiura; Akito Nagatsu; Nobutoshi Murakami; 📂 Article 📅 1998 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 223 KB

## Abstract 5,8‐Methanoquinazolines fused with 1,2,4‐triazole 4–5, tetrazole 6, and 1,2,4‐triazine 8 were prepared starting from 2‐hydrazino‐5,8‐methanoquinazoline 3. Compound 3 and 6 showed the most potent central nervous system (CNS) stimulant activities.

Synthesis and central nervous system sti
Synthesis and central nervous system stimulant activity of camphor-1,2,3-triazine fused with diphenylcyclopropenone and camphor-1,2,3-triazine n-oxides
✍ Shin-Ichi Nagai; Taisei Ueda 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 149 KB

## Abstract Reactions of camphor‐1,2,3‐triazine 1 with diphenylcyclopropenone 2 gave two cycloadducts; 6,9‐methanopyrazolo[1,2‐__b__][1,2,3]benzotriazinones 3–4. Oxidation of 1 with 3‐chloroperbenzoic acid gave 1‐oxide 5 as the major compound along with a trace of 1,2‐dioxide 6.