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Synthesis and central nervous system stimulant activity of 5,8-methanoquinazolines fused with 1,2,4-triazole, tetrazoleand 1,2,4-triazine

✍ Scribed by Shin-Icbi Nagai; Taisei Ueda; Satoe Sugiura; Akito Nagatsu; Nobutoshi Murakami; Jinsaku Sakakibara; Michiko Fujita; Yoshiki Hotta

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
223 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

5,8‐Methanoquinazolines fused with 1,2,4‐triazole 4–5, tetrazole 6, and 1,2,4‐triazine 8 were prepared starting from 2‐hydrazino‐5,8‐methanoquinazoline 3. Compound 3 and 6 showed the most potent central nervous system (CNS) stimulant activities.

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