ChemInform Abstract: Synthesis and Central Nervous System Stimulant Activity of 5,8-Methanoquinazolines Fused with Imidazole, Thiadiazole, Pyrimidine, and 1,3,5-Triazine.

✍ Scribed by S. NAGAI; T. UEDA; A. NAGATSU; K. NAKAOKA; N. MURAKAMI; J. SAKAKIBARA; M. FUJITA; Y. HOTTA

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 39 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199838222

✦ Synopsis

Synthesis and Central Nervous System Stimulant Activity of 5,8-Methanoquinazolines Fused with Imidazole, Thiadiazole, Pyrimidine, and1,3,5-Triazine. -The synthesis of a variety of new camphor-pyrimidines fused with azoles [cf. (VII), (XV), (XVI)], pyrimidines [cf.

(IX), (XIII)], and triazine (XI) from readily accessible 3-amino-5,8methanoquinazoline (V) is described. Most of these compounds show CNS stimulant activity. -(NAGAI, S.;