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Synthesis and Biological Evaluation of 7-Alkenyl Homocamptothecins as Potent Topoisomerase I Inhibitors

✍ Scribed by Lingjian Zhu; Xianghua Zhang; Ning Lei; Wenfeng Liu; Zhenyuan Miao; Chunlin Zhuang; Chunquan Sheng; Wei Guo; Guoqiang Dong; Jianzhong Yao; Pengfei Cheng; Wannian Zhang


Book ID
112015974
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
718 KB
Volume
9
Category
Article
ISSN
1612-1872

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Synthesis and Biological Evaluation of N
✍ Lingjian Zhu; Pengfei Cheng; Ning Lei; Jianzhong Yao; Chunquan Sheng; Chunlin Zh πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 334 KB πŸ‘ 2 views

## Abstract Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (ο£ΏCH~2~ο£Ώ) spacer between the alcohol moiety and carbonyl group of the classical six‐membered α‐hydroxylactone ring. This modification provides higher lactone stability and did not impair its acti