𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors

✍ Scribed by Nagarajan, Muthukaman; Morrell, Andrew; Antony, Smitha; Kohlhagen, Glenda; Agama, Keli; Pommier, Yves; Ragazzon, Patricia A.; Garbett, Nichola C.; Chaires, Jonathan B.; Hollingshead, Melinda; Cushman, Mark

Book ID
127289405
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
356 KB
Volume
49
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Synthesis and Biological Evaluation of N
Synthesis and Biological Evaluation of Novel Homocamptothecins Conjugating with Dihydropyrimidine Derivatives as Potent Topoisomerase I Inhibitors
✍ Lingjian Zhu; Pengfei Cheng; Ning Lei; Jianzhong Yao; Chunquan Sheng; Chunlin Zh πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 334 KB πŸ‘ 2 views

## Abstract Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (ο£ΏCH~2~ο£Ώ) spacer between the alcohol moiety and carbonyl group of the classical six‐membered α‐hydroxylactone ring. This modification provides higher lactone stability and did not impair its acti