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Synthesis and Biological Assays of 9-(Acylamino)homocamptothecins as DNA Topoisomerase I Inhibitors

✍ Scribed by Guo, Wei; Dong, Guoqiang; Zhu, Lingjian; Liu, Wenfeng; Zhuang, Chunlin; Guo, Zizhao; Yao, Jianzhong; Sheng, Chunquan; Zhang, Huojun; Miao, Zhenyuan; Zhang, Wannian


Book ID
125852236
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
738 KB
Volume
10
Category
Article
ISSN
1612-1872

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Synthesis and Biological Evaluation of N
✍ Lingjian Zhu; Pengfei Cheng; Ning Lei; Jianzhong Yao; Chunquan Sheng; Chunlin Zh πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 334 KB πŸ‘ 2 views

## Abstract Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (ο£ΏCH~2~ο£Ώ) spacer between the alcohol moiety and carbonyl group of the classical six‐membered α‐hydroxylactone ring. This modification provides higher lactone stability and did not impair its acti