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ChemInform Abstract: Synthesis and Biological Evaluation of Novel Homocamptothecins Conjugating with Dihydropyrimidine Derivatives as Potent Topoisomerase I Inhibitors.

✍ Scribed by Chunquan Sheng; et al. et al.

Publisher
John Wiley and Sons
Year
2012
Weight
13 KB
Volume
43
Category
Article
ISSN
0931-7597

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Synthesis and Biological Evaluation of N
Synthesis and Biological Evaluation of Novel Homocamptothecins Conjugating with Dihydropyrimidine Derivatives as Potent Topoisomerase I Inhibitors
✍ Lingjian Zhu; Pengfei Cheng; Ning Lei; Jianzhong Yao; Chunquan Sheng; Chunlin Zh πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 334 KB πŸ‘ 2 views

## Abstract Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (ο£ΏCH~2~ο£Ώ) spacer between the alcohol moiety and carbonyl group of the classical six‐membered α‐hydroxylactone ring. This modification provides higher lactone stability and did not impair its acti