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ChemInform Abstract: Synthesis and Biological Evaluation of Novel 7-Acyl Homocamptothecins as Toposiomerase I Inhibitors.

✍ Scribed by Wannian Zhang; et al. et al.

Publisher
John Wiley and Sons
Year
2011
Weight
39 KB
Volume
42
Category
Article
ISSN
0931-7597

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## Abstract Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (ο£ΏCH~2~ο£Ώ) spacer between the alcohol moiety and carbonyl group of the classical six‐membered α‐hydroxylactone ring. This modification provides higher lactone stability and did not impair its acti