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Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738

✍ Scribed by Masae Sawada; Ken-ichi Washizuka; Hiroyuki Okumura

Book ID
108073177
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
206 KB
Volume
14
Category
Article
ISSN
0960-894X

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## Abstract Squalene epoxidase is a microsomal enzyme that catalyzes the conversion of squalene to 2,3‐oxidosqualene and is an important control site in the cholesterol synthetic pathway. FR194738 is a potent inhibitor of hepatic squalene epoxidase from dogs, hamsters, and rats with IC~50~ values o