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Synthesis and Biological Activity of a Novel Squalene Epoxidase Inhibitor, FR194738.

✍ Scribed by Masae Sawada; Ken-ichi Washizuka; Hiroyuki Okumura

Publisher: John Wiley and Sons
Year: 2004
Weight: 100 KB
Volume: 35
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200423129

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## Abstract Squalene epoxidase is a microsomal enzyme that catalyzes the conversion of squalene to 2,3‐oxidosqualene and is an important control site in the cholesterol synthetic pathway. FR194738 is a potent inhibitor of hepatic squalene epoxidase from dogs, hamsters, and rats with IC~50~ values o

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