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1.P.209 Lipid lowering effect of FR194738, a novel squalene epoxidase inhibitor, in hamsters and dogs

✍ Scribed by M. Sawada; H. Hagihara; K. Washizuka; H. Okumura; J. Seki; K. Tanaka

Book ID: 119437256
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 360 KB
Volume: 134
Category: Article
ISSN: 0021-9150
DOI: 10.1016/s0021-9150(97)88388-8

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## Abstract Squalene epoxidase is a microsomal enzyme that catalyzes the conversion of squalene to 2,3‐oxidosqualene and is an important control site in the cholesterol synthetic pathway. FR194738 is a potent inhibitor of hepatic squalene epoxidase from dogs, hamsters, and rats with IC~50~ values o

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