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Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells

✍ Scribed by Masae Sawada; Masahiko Matsuo; Hiroyuki Hagihara; Noriko Tenda; Akira Nagayoshi; Hiroyuki Okumura; Ken-ichi Washizuka; Jiro Seki; Toshio Goto

Book ID
114014342
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
95 KB
Volume
431
Category
Article
ISSN
0014-2999

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Sulfonamide Derivatives of Benzylamine Block Cholesterol Biosynthesis in HepG 2 Cells: A New Type of Potent Squalene Epoxidase Inhibitors. -A new class of sulfonamide derivatives (VI) which act as mammalian squalene epoxidase inhibitors is synthesized. It is shown that thienyl residue is necessary