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ChemInform Abstract: Sulfonamide Derivatives of Benzylamine Block Cholesterol Biosynthesis in HepG2 Cells: A New Type of Potent Squalene Epoxidase Inhibitors.

✍ Scribed by J.-P. GOTTELAND; C. LOUBAT; B. PLANTY; D. JUNQUERO; A. DELHON; S. HALAZY

Publisher: John Wiley and Sons
Year: 2010
Weight: 36 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199840077

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✦ Synopsis

Sulfonamide Derivatives of Benzylamine Block Cholesterol Biosynthesis in HepG 2 Cells: A New Type of Potent Squalene Epoxidase Inhibitors.

-A new class of sulfonamide derivatives (VI) which act as mammalian squalene epoxidase inhibitors is synthesized. It is shown that thienyl residue is necessary for the desired activity. The most potent derivative within this series found to be derivative (VIa).

-(GOTTELAND,

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