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Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase

โœ Scribed by Yoshikazu Iwasawa; Masahiro Hayashi; Takashi Nomoto; Jun Shibata; Morihiro Mitsuya; Kenj Hirota; Mari Yonemoto; Toshio Kamei; Keiko Miura; Koji Tomimoto


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
224 KB
Volume
5
Category
Article
ISSN
0960-894X

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The title compound and its Cdpivaloyloxy methyl (PGM) ester have been synthesized by converting zaragozic acid A to the key intermediate of the protected C3-hydroxymethyl compound 6. Subsequent radical deoxygcnation via the Barton-McCombie procedure. followed by dqnvtection, affarded the product 11