𝔖 Bobbio Scriptorium
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Synthesis and biodistribution of radioiodinated-5-iodonicotine

✍ Scribed by S. M. Chan; G. P. Basmadjian; D. F. Marten; S. A. Sadek; R. A. Magarian; J. R. Grunder; R. D. Ice

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
327 KB
Volume
20
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

5‐Bromonicotine, synthesized from nicotinic acid, was autoclaved with Na^125^I in the presence of copper sulfate and glacial acetic acid to give 5‐[^125^I]iodonicotine. The radiochemical yield was 25.3%. The specific activity of the product was approximately 61 mCi/mmole. Biodistribution studies of 5‐[^125^I]iodonicotine, performed in rats, showed that the labelled compound accummulated rapidly in the brain and the adrenal gland. The highest uptake of radioactivity in these organs occurred at 5 minutes after administration. The brain‐to‐blood and the adrenal‐to‐blood ratios at this time interval were 2.6:1 and 3.3:1 respectively.

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