𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis and biodistribution of acetyl-3,5-br-82-dibromosalicylic acid

✍ Scribed by Steven H. Wong; Richard P. Spencer

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
375 KB
Volume
18
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Acetyl‐3,5‐Br‐82‐dibromosalicylic acid (dibromoaspirin) was synthesized by radiobromination of salicylic acid to yield 3,5‐dibromosalicylic acid, followed by acetylation of this intermediate. Biodistribution studies in mice with and without a neuroblastoma showed that the tumor/blood radioactivity ratio was low (0.3 at one hour). Thin layer chromatography of urine indicated that only 20 to 30% of the radioactivity corresponded to dibromoaspirin. Studies of rabbits with inflammatory lesions showed that the inflammatory/normal tissue uptake ratio was 1.0 to 1.9. The RBC/plasma ratio was less than 0.5. Low uptake of radioactivity was likely due to rapid dehalogenation in vivo.

📜 SIMILAR VOLUMES

Enzymatic synthesis of 5-3H-indole-3-ace
Enzymatic synthesis of 5-3H-indole-3-acetic acid and 5-3H-indole-3-acetyl-myo-inositol from 5-3H-L-tryptophan
✍ Lech Michalczuk; John R. Chisnell 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 French ⚖ 309 KB

## Abstract Labeled 1‐tryptophan is converted to indole‐3‐acetamide and then to indole‐3‐acetic acid by enzymes from __Pseudomonas savastanoi__. Labeled indole‐3‐acetic acid can be converted to indole‐3‐acetyl‐1‐__0__‐β‐D‐glucose and to indole‐3‐acetyl‐__myo__‐inositol by enzymes from kernels of __