Four 1251-labelled nicotine analogs were synthesized: 3-(methylpropylaminomethyl)-, 3-(diethylaminomethyl)-, 3-(isopropylaminomethy1)-, and 3-(diisopropylaminomethy1)-5-[ 1251]-iodopyridines. 5-Bromonicotinic acid was acylated with thionyl chloride and then reacted with the appropriate primary and s
Synthesis and evaluation of radioiodinated clofilium analogs
โ Scribed by V. Quiquero; D.H. Hunter; P. Culbert; P.L. Zabel; L.M. Gecelovsky
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 52 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
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Phosphonate analogs / Mannose 6-phosphate (M6P) / Receptors / Recognition markers / Phosphonates / Natural products Two ฮฒ-hydroxyphosphonate analogs of M6P have been prepared by condensation of the lithiated anion of methyldiethylphosphonate with the C-6 carbonyl of a mannose derivative. The diaster
## Abstract 5โBromonicotine, synthesized from nicotinic acid, was autoclaved with Na^125^I in the presence of copper sulfate and glacial acetic acid to give 5โ[^125^I]iodonicotine. The radiochemical yield was 25.3%. The specific activity of the product was approximately 61 mCi/mmole. Biodistributio