Tumor localizing agents VI. Radioiodinated analogs of dichlorodiphenyldichloroethane (DDD)

✍ Scribed by R. E. Counsell; V. V. Ranade; P. Pocha; R. E. Willette; W. Diguilio

• Publisher: John Wiley and Sons
• Year: 1968
• Tongue: English
• Weight: 427 KB
• Volume: 57
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600571005

✦ Synopsis

observed with other excipients studied in this investigation exhibit smaller changes, the spectral and color differences observed were indicative of some interaction. The diversity of the excipient or other type materials found in Table also indicates that this ferrous sulfate interaction is widespread.

It should therefore be recognized that although analytical data with respect to a dosage form may substantiate the presence of the labeled amount of metallic ion, the form in which it exists in this product may certainly be one that is not available for a therapeutic response (11). Based on this ferrous sulfate-excipient interaction data, it does not seem unreasonable that other iron salts as well as salts used for other therapeutic purposes would also undergo such a phenomenon. A consideration of this possibility is therefore necessary in the development of pharmaceutical products.