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Synthesis and biodistribution of radioiodinated selenonium salts: Potential myocardial imaging agents

✍ Scribed by A. S. Parikh; G. P. Basmadjian; D. L. Gilliland; R. B. Greenwood; J. A. Rieger; A. Weaver

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
388 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

S W R Y

(2-[ lZ5I ]iodobenzyl)benzylmethylselenonium tetraf luoroborate (L) and (0-[ 1251]iodobenzyl)dibenzylselenonium tetrafluor b rate (2) were synthesized by methylation and benzylation of ~-[PzPI]iodobenzyl benzyl selenide respectively. The starting compound 2-iodobenzyl benzyl selenide was radioiodinated with sodium [ 1251]iodide by melt-exchange in a sealed ampoule maintained at 75OC for 12 hours, with subsequent chromatographic purification yielding the pure compound in a radiochemical yield of 33.0% and specific activity of at least 68.0 mCi/mmol. Tissue distribution studies of compounds 1 and 2, performed i n rats, showed that the labelled compounds accumulated rapidly in the heart. The maximum heart-to-blood ratios for compounds 1 and 2 were 4.2:l and G.4:1 compared to that of 2.0:l for previously synthesized [75Se]Trimethylselenonium Iodide (2).

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