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The synthesis and biodistribution of 3-(4′-[125I]-iodophenyl)-4-aminobutyric acid, a radioiodinated analogue of baclofen

✍ Scribed by Y. Wakita; M. Kojima; S. W. Schwendner; D. McConnell; R. E. Counsell

Publisher: John Wiley and Sons
Year: 1990
Tongue: French
Weight: 466 KB
Volume: 28
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580280202

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✦ Synopsis

Abstract

Baclofen has been found to bind to receptors in the central nervous system that are specific for γ‐aminobutyric acid (GABA), a well known inhibitory neurotransmitter. This paper describes the synthesis of a radioiodinated analog of baclofen as part of an effort to develop receptor probes useful in single photon emission computed tomography. Preliminary biodistribution studies showed the radioiodinationed analog to be essentially stable to in vivo deiodination and have a distribution profile similar to that of baclofen.

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