Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety
โ Scribed by Yong Koo Kang; Kye Jung Shin; Kyung Ho Yoo; Kyung Jae Seo; Chang Yong Hong; Chang-Seok Lee; Seung Yong Park; Dong Jin Kim; Sang Woo Park
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 155 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0960-894X
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๐ SIMILAR VOLUMES
Methodology for preparing a series of novel or-amino-acids and their derivatives containing an isoxazole ring as a substituent is presented. The synthesis starts from a readily available L-serine derivative from which, depending on the synthetic strategy, it is possible to obtain isoxazol-3-yl or is
A series of sulphur-linked and carbon-linked lipophLlic carhapenems has been prepared and evaluated for antibacterial activity in vitro and in vivo and for affinity for PBP2' of Staphylococcus aureus. Potent activity in vitro against methicillin-resistant S. aureus and methicillin-resistant coagulas