✦ LIBER ✦

Synthesis and antibacterial activity of lipophilic carbapenems with anti-MRSA activity

✍ Scribed by Jean Claude Arnould; Ruth N Illingworth; Wright W Nichols; R. Geoffrey Wilson

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 326 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00450-7

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✦ Synopsis

A series of sulphur-linked and carbon-linked lipophLlic carhapenems has been prepared and evaluated for antibacterial activity in vitro and in vivo and for affinity for PBP2' of Staphylococcus aureus. Potent activity in vitro against methicillin-resistant S. aureus and methicillin-resistant coagulase negative staphylococci was observed despite IC5o values for PBP2' being higher than the MIC.

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