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ChemInform Abstract: Synthesis of Novel Di- and Tricationic Carbapenems with Potent anti-MRSA Activity.

โœ Scribed by Takahisa Maruyama; Yasuo Yamamoto; Yuko Kano; Mizuyo Kurazono; Eiki Shitara; Katsuyoshi Iwamatsu; Kunio Atsumi


Publisher
John Wiley and Sons
Year
2009
Weight
20 KB
Volume
40
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Novel Dithiocarbama
โœ N. OHTAKE; H. IMAMURA; H. KIYONAGA; H. JONA; M. OGAWA; S. OKADA; A. SHIMIZU; M. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB

Novel Dithiocarbamate Carbapenems with anti-MRSA Activity. -Novel carbapenems (IV) in which the C-2 atom is substituted by dithiocarbamate moiety are synthesized. Two of them, (IVa) and (IVb), show excellent in vitro and in vivo activity against methicillin-resistant Staphylococcus aureus. The loss