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Synthesis of new α-amino- acids containing the isoxazole moiety

✍ Scribed by Massimo Falorni; Giampaolo Giacomelli; Emanuela Spanu


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
200 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis


Methodology for preparing a series of novel or-amino-acids and their derivatives containing an isoxazole ring as a substituent is presented. The synthesis starts from a readily available L-serine derivative from which, depending on the synthetic strategy, it is possible to obtain isoxazol-3-yl or isoxazol-5-yl amino-acid precursors.


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✍ Zhong-Biao Zhang; Lian-Sheng Li; Ru-Yu Chen 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB 👁 1 views

A series of germasesquioxides and germatranes containing ␣-amino acid or ␣-aminophosphonic acid moieties was synthesized by the reaction of b-trichlorogermylpropionyl chloride with ␣-amino acid esters or ␣-aminophosphonates. The structures of all products were confirmed by 1 H NMR, 31 P NMR, and IR