Synthesis of new α-amino- acids containing the isoxazole moiety
✍ Scribed by Massimo Falorni; Giampaolo Giacomelli; Emanuela Spanu
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 200 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Methodology for preparing a series of novel or-amino-acids and their derivatives containing an isoxazole ring as a substituent is presented. The synthesis starts from a readily available L-serine derivative from which, depending on the synthetic strategy, it is possible to obtain isoxazol-3-yl or isoxazol-5-yl amino-acid precursors.
📜 SIMILAR VOLUMES
A series of germasesquioxides and germatranes containing ␣-amino acid or ␣-aminophosphonic acid moieties was synthesized by the reaction of b-trichlorogermylpropionyl chloride with ␣-amino acid esters or ␣-aminophosphonates. The structures of all products were confirmed by 1 H NMR, 31 P NMR, and IR