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Synthesis and Antibacterial Activities of New Carbapenems Having a Proline Reverse Amide Moiety at the C-2 Position

โœ Scribed by Soon Ho Hwang; Kye Jung Shin; Yong Koo Kang; Dong Jin Kim; Dong Chan Kim; Kyung Ho Yoo; Sang Woo Park; Kee Jung Lee


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
57 KB
Volume
331
Category
Article
ISSN
0365-6233

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The synthesis of a new series of 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octane-2,4-dione moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bateria are determined and the effect of substituent on the bicyclic ring as well as st