Synthesis and Antibacterial Activities of New 1β-Methylcarbapenems Having a 1,3-Diazabicyclo[3.3.0]octan-2,4-dione Moiety

✍ Scribed by Ki-Hong Nam; Chang-Hyun Oh; Young-Wan Ham; Ki-Soo Lee; Jung-Hyuck Cho

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 359 KB
• Volume: 330
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.19973300808

✦ Synopsis

The synthesis of a new series of 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octane-2,4-dione moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bateria are determined and the effect of substituent on the bicyclic ring as well as stereoisomerism was investigated.