Synthesis and activity of the glutathione analogue γ-(L-γ-azaglutamyl)-L-cysteinyl-glycine
✍ Scribed by CALCAGNI, A. ;DUPRÉ, S. ;LUCENTE, G. ;LUISI, G. ;PINNEN, F. ;ROSSI, D.
- Book ID
- 115099795
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 521 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0367-8377
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By using the chain to chain mode of cyclization the title glutathione analogue (4), containing the 11-membered disulfide ring replacing the native -Cys-Gly fragment, has been synthesized and characterized together with its reduced dithiol form gamma-Glu-Cys-Asp-Cys (5). The activity of (4) with gamm
## Abstract [Cys‐^14^CO]‐glutathione or N‐[N‐L‐γ‐glutamyl‐L‐cysteinyl‐^14^CO] glycine was prepared by chemical synthesis, with the L,L‐natural configuration and a radiochemical yield of 1% based on sodium [^14^C] cyanide. This labelled compound was used to obtain [Cys‐^14^CO] with a yield of 15%. [