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Synthesis and Activity of the Glutathione Analogue γ-(L-γ-Oxaglutamyl)-L-cysteinyl-glycine

✍ Scribed by Anna Calcagni; Silvestro Duprè; Gino Lucente; Grazia Luisi; Francesco Pinnen; Domenico Rossi; Alessandra Spirito

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 468 KB
Volume: 329
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.19963291105

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✦ Synopsis

Abstract

An efficient synthesis of the backbone modified glutathione analogue γ‐(L‐γ‐oxaglutamyl)‐L‐cysteinyl‐glycine (7), characterized by the presence of an urethane O‐CO‐NH linkage replacing the γ‐glutamylic CH~2~CO‐NH fragment is described. The new analogue has been fully characterized by ^1^H‐ and ^13^C‐NMR, and FAB‐MS. Compound 7 was tested for inhibition of γ‐glutamyl‐transferase activity and was found to be a non‐competitive inhibitor of hog kidney γ‐glutamyltransferase (EC 2.3.2.2).

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