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Synthesis of N-[N-L-γ-glutamyl-L-cysteinyl-(carbonyl-14C)]-glycine (glutathione-14C) and of [Cys-14CO]-(5S,6R)-LTC4

✍ Scribed by P. Parent; F. Leborgne; J. P. Lellouche; J. P. Beaucourt; A. Vanhove

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
451 KB
Volume
28
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[Cys‐^14^CO]‐glutathione or N‐[N‐L‐γ‐glutamyl‐L‐cysteinyl‐^14^CO] glycine was prepared by chemical synthesis, with the L,L‐natural configuration and a radiochemical yield of 1% based on sodium [^14^C] cyanide. This labelled compound was used to obtain [Cys‐^14^CO] with a yield of 15%. [Cys‐^14^CO]‐glutathione and [Cys‐^14^CO]LTC~4~ had a specific activity of 50 mCi/mmol (1.85 GBq/mmol).

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