ChemInform Abstract: Synthesis and Activity of the Glutathione Analogue γ-(L-γ- Azaglutamyl)-L-cysteinyl-glycine ( I).
✍ Scribed by A. CALCAGNI; S. DUPRE; G. LUCENTE; G. LUISI; F. PINNEN; D. ROSSI
- Book ID
- 112028365
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 26 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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## Abstract An efficient synthesis of the backbone modified glutathione analogue γ‐(L‐γ‐oxaglutamyl)‐L‐cysteinyl‐glycine (7), characterized by the presence of an urethane O‐CO‐NH linkage replacing the γ‐glutamylic CH~2~CO‐NH fragment is described. The new analogue has been fully characterized by ^1
By using the chain to chain mode of cyclization the title glutathione analogue (4), containing the 11-membered disulfide ring replacing the native -Cys-Gly fragment, has been synthesized and characterized together with its reduced dithiol form gamma-Glu-Cys-Asp-Cys (5). The activity of (4) with gamm