## Abstract Benzidine‐^15^N~2~ was prepared from 4,4′‐biphenyldicarboxamide‐^15^N~2~ by the Hofmann amide degradation. The diamide, in turn, was obtained from 4,4′‐biphenyldicarbonyl chloride and ammonium‐^15^N sulfate. An overall yield of 30–35% was obtained for the two steps. An attempted synthes
Syntheses with stable isotopes: Pyridine-15N
✍ Scribed by Thomas W. Whaley; Donald G. Ott
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- French
- Weight
- 126 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The acid‐catalyzed condensation of either 2‐ethoxy‐3,4‐dihydro‐2__H__‐pyran or pentanedial (glutaraldehyde) with ammonium‐^15^N chloride in the presence of methylene blue is a convenient one‐step synthesis of pyridine‐^15^N.
📜 SIMILAR VOLUMES
## Abstract The title compound was prepared from 4‐ethylthio‐1‐naphalenesulfonyl chloride in a two‐step synthesis with an overall yield of 56%. An alternative one‐step synthesis from 4‐ethylsulfonyl‐1‐naphthalenesulfonyl chloride was found to be unsuitable for nitrogen labeling.
## Abstract Sodium cyanide‐ ^13^C has been prepared in 65–70% overall yield from carbon‐^13^C monoxide in a three‐step synthesis proceeding through isopropyl formate‐ ^13^C and formamide‐ ^13^C as intermediates. Several. methods for the dehydration of formamide have been investigated.
## Abstract A three‐step synthesis of thymlne‐2,6‐^13^C~2~ from urea‐^13^C, sodium cyanide‐^13^C, and α‐bromopropionic acid is described. The last reaction involves hydrogenation of α‐cyano‐^13^C‐propionylurea‐^13^C in aqueous acetic acid and produces thymine‐2,6‐^13^C~2~ in 50–60% yield. The mecha
The synthesis of DL-2-amino-3-methyl-Cbutanoic-3,4-13C3 acid (DL-valine-13Cj) is described. Acetonitrile-2-13C was converted to 2methyl-13C-Z-thiazoline, which was dialkylated with methyl -13C iodide to give 2-(isopropyl-13C3) -2 -thiazoline. hydrolysis o f the isopropylthiazoline afforded 2-methyl
## Abstract Urea has been prepared from the reaction of carbon monoxide and ammonia in the presence of sulfur. The reaction has been applied to the synthesis of urea‐^13^C, urea‐^12^C, and urea‐^13^C‐^15^N~2~.