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Syntheses with stable isotopes: Thymine-2,6-13C2

✍ Scribed by Carolyn M. Redwine; Thomas W. Whaley

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
227 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A three‐step synthesis of thymlne‐2,6‐^13^C~2~ from urea‐^13^C, sodium cyanide‐^13^C, and α‐bromopropionic acid is described. The last reaction involves hydrogenation of α‐cyano‐^13^C‐propionylurea‐^13^C in aqueous acetic acid and produces thymine‐2,6‐^13^C~2~ in 50–60% yield. The mechanism of this reaction is discussed.

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