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Syntheses with stable isotopes: DL-valine-13C3

✍ Scribed by T. W. Whaley; V. N. Kerr; T. A. Lyle; G. H. Daub; E. S. Olsont

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
374 KB
Volume
16
Category
Article
ISSN
0022-2135

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✦ Synopsis

The synthesis of DL-2-amino-3-methyl-Cbutanoic-3,4-13C3 acid (DL-valine-13Cj) is described. Acetonitrile-2-13C was converted to 2methyl-13C-Z-thiazoline, which was dialkylated with methyl -13C iodide to give 2-(isopropyl-13C3) -2 -thiazoline. hydrolysis o f the isopropylthiazoline afforded 2-methyl -13C-propanal-2,3-13C2 , which was isolated as the bisulfite addition product. A modified Strecker synthesis with the bisulfite compound gave DL-valine-13Cx in good overall yield.

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