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Syntheses of carbon-14 and tritium labelled forms of bupropion hydrochloride – a novel antidepressant

✍ Scribed by John A. Hill; Jeffrey D. Scharver

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
418 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

Bupropion hydrochloride 1 (2-tert-butylamino-3'-chloropropiophenone hydrochloride) was synthesized in the [l*C]-labelled form with specific activity 36.5 mCi/mmol suitable for drug metabolism, distribution and pharmacokinetic studies.

The drug was synthesized in the [3H]-labelled form with specific activity 20.5 Cilmmol suitable for development of a radioimmunoassay procedure.

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