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A novel asymmetric synthesis of tritium and carbon-14 labeled (R)-ibuprofen

✍ Scribed by Yinsheng Zhang; Yang Hong; Che C. Huang; Daniel Belmont

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
118 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

An efficient asymmetric synthesis of tritium and carbon‐14 labeled R‐ibuprofen was achieved in good overall yield (15% and 47%, respectively) and excellent enantiomerical excess (>98% e.e.), using (4__R__, 5S)‐4‐methyl‐5‐phenyl‐2‐oxazolidinone as a chiral auxiliary. Copyright © 2006 John Wiley & Sons, Ltd.

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