✦ LIBER ✦

Syntheses of 14C-labelled prizidilol dihydrochloride

✍ Scribed by D Saunders; B H Warrington

Publisher: John Wiley and Sons
Year: 1985
Tongue: French
Weight: 396 KB
Volume: 22
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580220902

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✦ Synopsis

Two syntheses o f r a d i o l a b e l l e d p r i z i d l l o l d i h y d r o c h l o r l d e (DL)3-[2-(3-t-butylamino -2-hydroxypropoxy)phenyl]-6-hydrazinop y r i d a z l n e d i h y d r o c h l o r i d e ) a r e described. 1. A t e n stage synthesis (Scheme 1) which gave 14 [3,6y i e l d o f 0.91%. C2] p r i z l d l l o l d l h y d r o c h l o r l d e (0) I n an o v e r a l l 2. A l a t e r , a l t e r n a t i v e procedure (scheme 2) leading t o 14 [4,5-C2] p r i z i d i l o l d i h y d r o c h l o r i d e (B) w i t h an o v e r a l l radiochemical y i e l d o f 8%. 14 Keywords: P r i z i d i l o l d i h y d r o c h l o r i d e , [1,4acid, [2,3-C2] s u c c i n i c anhydrtde, p r e p a r a t i v e l a y e r chromatography, reverse i s o t o p e d i l u t i o n , 14C-labelled.

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