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Syntheses of 14C-labelled monoacidic metabolites of dithiopyr

✍ Scribed by Mohammad E. Mehrsheikh; Lane A. Clizbe; Harbhajan Singh; Wr Purdum

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
210 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Convenient methods for the selective hydrolysis of the thioester groups of dithiopyr to the corresponding carboxylic acid are described. 2-@ifluoromethyl)-4-(2-methylpropyl)-5-[ (methylthio)carbnyl] -6-(trifluoromethyl)-3-pyridine-4-~~C-carboxylic acid (2) was obtained by simple potassium hydroxide hydrolysis of 14C-labelled dithiopyr. A more involve strategy was necessary for the preparation of the isomeric carboxylic acid 6-(difluoromethyl)-4-(2-methylpropyl)-5-[(methylthio) carbonyl]-2-(trifluoromethyl)-3-pyridine-4-14Ccarboxylic acid Q)

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