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Syntheses of 14C-mustard-labelled and 14C-leucine-labelled Asaley

✍ Scribed by D. Farquhar; K. Lu; T. L. Loo

Publisher: John Wiley and Sons
Year: 1980
Tongue: French
Weight: 429 KB
Volume: 17
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580170202

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✦ Synopsis

Abstract

The synthesis of Asaley labelled with ^14^C in the mustard (Asaley‐must‐^14^C) or the leucine (Asaley‐leu‐^14^C) moiety is described. In the former, ethyl pamino‐N^α^‐acetyl‐DL‐phenylalanyl‐L‐leucinate was reacted with ethylene oxide(U)‐^14^C to give the bis(hydroxyethyl)amino analogue, which was converted to Asaley by treatment with thionyl chloride. Asaley labelled in the leucine moiety was prepared by condensation of N‐acetylsarcolysin with ethyl leucinate(U)‐^14^C in the presence of dicyclohexylcarbodiimide. The identity of the products was established by spectroscopic, chemical, and chromatographic techniques.

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