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Subtype-specific stimulation of [35S]GTPγS binding by recombinant α2-adrenoceptors

✍ Scribed by Juha M. Peltonen; Marjo Pihlavisto; Mika Scheinin

Book ID
114016523
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
99 KB
Volume
355
Category
Article
ISSN
0014-2999

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Subtype-specific stimulation of [35S]GTP
Subtype-specific stimulation of [35S]GTPγS binding by recombinant α2-adrenoceptors
✍ Juha M. Peltonen; Marjo Pihlavisto; Mika Scheinin 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 99 KB

We measured agonist-stimulated binding of the stable GTP-analog guanosine-5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS) as a functional assay to monitor G-protein activation by recombinant human alpha2-adrenoceptor subtypes alpha2A, alpha2B and alpha2C. (-)-Noradrenaline was a full agonist in all