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Subacute Toxicity of a Novel Inhibitor of Acyl-CoA: Cholesterol Acyltransferase in Beagle Dogs

โœ Scribed by M.A. Dominick; E.J. McGuire; J.F. Reindel; W.F. Bobrowski; T.M.A. Bocan; A.W. Gough


Book ID
115608180
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
880 KB
Volume
20
Category
Article
ISSN
0272-0590

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โœ F. L. S. Tse; J. M. Jaffe ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 540 KB

The pharmacokinetics of 3-(decyldimethylsilyI)-N-[2-(4-methylphenyl)-lphenylethyllpropanamide (DMPP), an inhibitor of acyl-CoA:cholesterol acyltransferase, have been studied in the dog and the rat using "C and 'H dual-labelled drug. In both species, gastrointestinal absorption of DMPP was slow and