๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Inhibitors of acyl-CoA:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents

โœ Scribed by Trivedi, Bharat K.; Holmes, Ann; Stoeber, Terri L.; Blankley, C. John; Roark, W. Howard; Picard, Joseph A.; Shaw, Mary K.; Essenburg, Arnold D.; Stanfield, Richard L.; Krause, Brian R.


Book ID
118161524
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
969 KB
Volume
36
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Pyridazine derivatives as novel acyl-coa
โœ Arianna Gelain ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 96 KB

Acyl-CoA:cholesterol acyltransferase (E.C.2.3.1.26, ACAT) is a microsomial enzyme that catalyses the formation of cholesteryl esters by acylation of cholesterol with long chain fatty acylCoA [1]. ACAT plays important roles in cellular homeostasis and in the early stages of atherosclerosis. Therefor

Inhibitors of acyl-coa:cholesterol acylt
โœ Bruce D. Roth; W. Howard Roark; Joseph A. Picard; Richard L. Stanfield; Richard ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 206 KB

A series of sulfonylureas were prepared and tested for the ability to inhibit the enzyme acyl-CoA: cholesterol acyltransferase (ACAT) in vitro and lower plasma cholesterol in cholesterol-fed rats in vivo. Although compounds from this series were generally weak inhibitors of ACAT in vitro, several di

Tetrazole-substituted ureas as inhibitor
โœ Claude F Purchase II; Andrew D White; Maureen K Anderson; Thomas M.A Bocan; Rich ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 327 KB

A novel series of tetrazole-substituted ureas 2 were prepared from weakly nucleophilic amines using a new coupling method. The ureas were found to potently inhibit liver ACAT in vitro and lower total serum cholesterol in vivo. A comparison of urea 2b and the anti-atherosclerotic CI-976 in a long-ter