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ChemInform Abstract: Heterocyclic Ureas: Inhibitors of Acyl-CoA:Cholesterol O- Acyltransferase (ACAT) as Hypocholesterolemic Agents.

✍ Scribed by A. D. WHITE; M. W. CRESWELL; A. W. CHUCHOLOWSKI; C. J. BLANKLEY; M. W. WILSON; R. F. BOUSLEY; A. D. ESSENBURG; K. L. HAMELEHLE; B. R. KRAUSE; R. L. STANFIELD; M. A. DOMINICK; M. NEUB

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199707147

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## Abstract Structure‐activity relationship studies lead to the discovery of compound (I), which shows potent ACAT inhibitory activity (IC~50~ = 12 nM) and good pharmacokinetic profile in mice.