✦ LIBER ✦
ChemInform Abstract: Discovery of a Potent and Orally Available Acyl-CoA: Cholesterol Acyltransferase Inhibitor as an Antiatherosclerotic Agent: (4-Phenylcoumarin)acetanilide Derivatives.
✍ Scribed by Masaki Ogino; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2012
- Weight
- 21 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
Structure‐activity relationship studies lead to the discovery of compound (I), which shows potent ACAT inhibitory activity (IC~50~ = 12 nM) and good pharmacokinetic profile in mice.