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Inhibitors of acyl-coa:cholesterol acyltransferase (ACAT). 15. sulfonylurea inhibitors with excellent hypocholesterolemic activity in vivo.

✍ Scribed by Bruce D. Roth; W. Howard Roark; Joseph A. Picard; Richard L. Stanfield; Richard F. Bousley; Maureen K. Anderson; Katherine L. Hamelehle; Reynold Homan; Brian R. Krause

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 206 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00408-l

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✦ Synopsis

A series of sulfonylureas were prepared and tested for the ability to inhibit the enzyme acyl-CoA: cholesterol acyltransferase (ACAT) in vitro and lower plasma cholesterol in cholesterol-fed rats in vivo. Although compounds from this series were generally weak inhibitors of ACAT in vitro, several displayed excellent hypocholesterolemic activity in vivo.

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