## Abstract For Abstract see ChemInform Abstract in Full Text.
Novel Acyl-CoA:Cholesterol Acyltransferase Inhibitors. Synthesis and Biological Activity of 3-Quinolylurea Derivatives
β Scribed by Tawada, Hiroyuki; Harcourt, Myles; Kawamura, Noriaki; Kajino, Masahiro; Ishikawa, Eiichiro; Sugiyama, Yasuo; Ikeda, Hitoshi; Meguro, Kanji
- Book ID
- 115528129
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 719 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
Acyl-CoA:cholesterol acyltransferase (E.C.2.3.1.26, ACAT) is a microsomial enzyme that catalyses the formation of cholesteryl esters by acylation of cholesterol with long chain fatty acylCoA [1]. ACAT plays important roles in cellular homeostasis and in the early stages of atherosclerosis. Therefor
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
## Abstract Among the title derivatives, compound (I) exhibits 16βfold stronger antiβfoam cell formation activity, 3βfold stronger hepatic ACAT inhibitory activity, similar LDL oxidative activity and 2βfold more potent protective activity against macrophage cell death compared to the known ACAT inh